Transdermal venous access locking solutions

A method of disinfecting an implanted catheter from bacteria and fungi, the method comprising:

• introducing to a lumen of a catheter a microbial growth inhibiting solution comprising a C10 or C12 carboxylate antimicrobial agent and a chelating agent, wherein the C10 or C12 carboxylate antimicrobial agent is present in an amount ranging from about 0.05 mg/mL to about 5 mg/mL and the chelating agent is present in an amount ranging from about 0.01 mg/mL to about 2 mg/mL, and wherein the solution has a pH of 5.2 or less.

A method for coating a medical device, the method comprising:

• exposing the medical device to a microbial growth inhibiting solution for a sufficient amount of time to provide a coating on the exposed surface of the device, wherein the microbial growth inhibiting solution comprises a C10 or C12 carboxylate antimicrobial agent and a chelating agent, wherein the C10 or C12 carboxylate antimicrobial agent is present in an amount ranging from about 0.05 mg/mL to about 5 mg/mL and the chelating agent is present in an amount ranging from about 0.01 mg/mL to about 2 mg/mL, and wherein the solution has a pH of 5.2 or less.

A medical device coated with a microbial growth inhibiting solution comprising a C10 or C12 carboxylate antimicrobial agent and a chelating agent, wherein the C10 or C12 carboxylate antimicrobial agent is present in an amount ranging from about 0.05 mg/mL to about 5 mg/mL and the chelating agent is present in an amount ranging from about 0.01 mg/mL to about 2 mg/mL, and wherein the solution has a pH of 5.2 or less.

A method for locking and/or flushing an implanted catheter, the method comprising:

• filling a lumen of an implanted catheter open to a body lumen with a microbial growth inhibiting solution comprising a C10 or C12 carboxylate antimicrobial agent and a chelating agent, wherein the C10 or C12 carboxylate antimicrobial agent is present in an amount ranging from about 0.05 mg/mL to about 5 mg/mL and the chelating agent is present in an amount ranging from about 0.01 mg/mL to about 2 mg/mL, and wherein the solution has a pH of 5.2 or less.

A kit for locking and/or flushing an implanted catheter, the kit comprising:

• a container holding a volume of a microbial growth inhibiting solution comprising a C10 or C12 carboxylate antimicrobial agent and a chelating agent, wherein the C10 or C12 carboxylate antimicrobial agent is present in an amount ranging from about 0.05 mg/mL to about 5 mg/mL and the chelating agent is present in an amount ranging from about 0.01 mg/mL to about 2 mg/m, and wherein the solution has a pH of 5.2 or less L;
• and
• an implantable catheter lumen that receives the microbial growth inhibiting solution.

A kit for locking and/or flushing an implanted catheter, the kit comprising:

• a container having a first compartment holding a C10 or C12 carboxylate antimicrobial agent and a chelating agent in powder form and a second compartment holding a pharmacologically acceptable carrier solution, wherein the C10 or C12 carboxylate antimicrobial agent is present in an amount ranging from about 0.05 mg/mL to about 5 mg/mL and the chelating agent is present in an amount ranging from about 0.01 mg/mL to about 2 mg/mL when mixed with the pharmacologically acceptable carrier solution, and wherein the solution has a pH of 5.2 or less.