Directly injectable formulations which provide enhanced cryoprotection of cell products
AssigneeAduro Gvax Inc.
InventorsDavid Frey, Andy Lin, Gautum Banik
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Abstract
This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO or glycerol.
Claims14
A suspension of recombinant live cancer cells comprising a plurality of recombinant live cancer cells in a cryoprotective medium, wherein the cryoprotective medium comprises about 5% by weight to about 22% by weight of a hydroxyethyl starch (HES) and about 5% by weight to about 10% by weight of DMSO, and
- wherein the recombinant live cancer cells express granulocyte-macrophage colony stimulating factor (GM-CSF).
A cryopreserved, frozen suspension of recombinant live cancer cells, comprising a plurality of recombinant live cancer cells in a cryoprotective medium, wherein the cryoprotective medium comprises about 5% by weight to about 22% by weight of a hydroxyethyl starch (HES) and about 5% by weight to about 10% by weight of DMSO, and
- wherein the recombinant live cancer cells express granulocyte-macrophage colony stimulating factor (GM-CSF).
Dependencies are inferred from the claim text.