Cystine diamide analogs for the prevention of cystine stone formation in cystinuria

A pharmaceutical composition comprising a compound having formula (A):

• and pharmaceutically acceptable salts, solvates and prodrugs thereof wherein
• each R and R′ pair are independently selected from the group consisting of (i) and (ii);
• (i) R and R′ are independently selected form the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl,
• (ii) R and R′ together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure, said heterocyclic ring structure having the formula (B)
• wherein R and R′ of at least one pair together form a ring structure having the formula (B)
• wherein Z is N-Q;
• and Q is hydrogen or an alkyl;
• and r is 1-3;
• and
• X is hydrogen, or an alkyl;
• and Y is O or S;
• in a pharmaceutically acceptable carrier.