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US 9,428,442 B2Granted
Process for the preparation of Clomiphene
AssigneeF.I.S. Fabbrica Italiana Sintetici S.p.A.
InventorsSiro Serafini, Pierluigi Padovan
Life of this patent
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Abstract
An improved process for the preparation of the active pharmaceutical ingredient Clomiphene and, in particular, trans-Clomiphene, using acetic acid or trifluoroacetic acid is disclosed.
Claims12
A process for the preparation of Clomiphene and salts thereof, comprising reacting a mixture of geometric isomers of formula (V-E) and (V-Z) or salts thereof:
- in an organic solvent with a chlorinating agent, wherein the reacting is performed in presence of acetic acid or trifluoroacetic acid.
A process for the preparation of trans-Clomiphene and salts thereof, comprising reacting a mixture of geometric isomers of formula (V-E) and (V-Z) or salts thereof:
- in an organic solvent with a chlorinating agent, wherein the organic solvent is methylene chloride and the reacting is performed in presence of acetic acid or trifluoroacetic acid.
Dependencies are inferred from the claim text.