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US 9,428,431 B2Granted
Compositions comprising CB receptor agonists, uses thereof and methods for their preparation
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsItai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
Life of this patent
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Abstract
Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
Claims14
A composition comprising the (3R, 4R, 6R)-diastereomer of a compound of general formula (II):
- wherein
- is a double bond;
- R1 is independently selected from —R2OR3, —C(═O)R4, and —OC(═O)R5;
- R2 is a C1-C5 straight or branched alkylene;
- R3 is selected from the group consisting of H, —C(═O)OH, straight or branched C1-C5 alkyl, straight or branched C1-C5 acyl, and straight or branched C1-C5 amide;
- R4, and R5 are independently selected from the group consisting of H, OH, straight or branched C1-C5 alkyl, straight or branched C1-C5alkoxy, and straight or branched C1-C5 amine;
- R6 and R7 are each independently selected from H, and —OR8 wherein R8 is a straight or branched C1-C5 alkyl, provided that at least one of R6 and R7 is different than H;
- and
- R9 is independently selected from an optionally substituted straight or branched C6-C12 alkyl, an optionally substituted straight or branched C5-C9 alkoxy, and an optionally substituted straight or branched C1-C7 ether.
6 more elements
Dependencies are inferred from the claim text.