Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
AssigneeChiesi Farmaceutici S.p.A.
InventorsClaudio Cafiero, Federico Tosini
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Abstract
Cohesive high-dosage strength micronized active ingredients may be dispersed in dry powder formulations for inhalation comprising carrier particles, by use of the apparatus described herein.
Claims20
A process for dispersing a cohesive, high-dosage strength micronized active ingredient in a dry powder formulation comprising carrier particles, said process comprising:
- (i) loading said active ingredient and a portion of said carrier particles in a dispersion capsule comprising a cylindrical room (1) with a lateral boundary made of a sieving mesh (2), said room (1) containing grinding balls (3), which can be closed by a screw cap (4) on the top, two longitudinal roads (6), and a disk (5), wherein the capsule is connected to said disk by said two longitudinal rods;
- (ii) fitting said capsule to a drum, filled with the remaining part of the carrier;
- (iii) inserting said drum into a rotating body mixer apparatus;
- and
- (iv) operating said rotating body mixer to mix the whole powder.
An apparatus in the form of a capsule for dispersing a cohesive high-dosage strength micronized active ingredient, said capsule comprising a cylindrical room (1) with a lateral boundary made of a sieving mesh (2) containing grinding balls (3) and which can be closed by a screw cap (4) on the top, two longitudinal rods (6), and a disk (5) wherein the capsule is connected to said disk by said two longitudinal rods.
Dependencies are inferred from the claim text.