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US 9,290,538 B2Granted
Cell-permeable peptide inhibitors of the JNK signal transduction pathway
AssigneeXigen Inflammation Ltd.
InventorChristophe Bonny
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Abstract
Protein kinase inhibitors and more specifically inhibitors of the protein kinase c-Jun amino terminal kinase are herein described. Additionally, JNK inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with JNK signaling are herein provided.
Claims18
A chimeric peptide consisting of a first domain and a second domain directly linked by a covalent bond or linked by a linker sequence of 1 to 10 amino acids,
- the first domain comprising a trafficking sequence, and
- the second domain consisting of a c-Jun N-terminal kinase (JNK) inhibitor sequence of SEQ ID NO:
- 2 or a variant sequence of SEQ ID NO:
- 2 with 1 or 2 amino acids deleted from either terminus of SEQ ID NO:
- 2,
- wherein the trafficking sequence comprises the amino acid sequence of SEQ ID No:
- 5, 6, 7 or 8 or a sequence variant of SEQ ID NO:
- 5 or 6 with 1 or 2 amino acids deleted from either terminus of SEQ ID NO:
- 5 or 6, and wherein the trafficking sequence and the JNK inhibitor sequence are composed exclusively of D-enantiomeric amino acids.
6 more elements
Dependencies are inferred from the claim text.