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US 9,243,281 B2Granted
Neuroprotective chemicals and methods for identifying and using same
AssigneeBoard of Regents, The University of Texas System
InventorsSteven L. McKnight, Joseph M. Ready, Andrew A. Pieper, Gelin Wang, Ting Han
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Abstract
Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
Claims18
A method for identifying a compound having cell-protective activity, comprising:
- exposing a population of cells to a test compound and a DNA-damaging agent;
- determining survival rate of the population of cells;
- wherein an increase in the survival rate compared to a control that is not treated with the test compound is indicative of cell-protective activity of the test compound;
- and
- incubating the test compound with nicotinamide phosphoribosyltransferase (NAMPT) and measuring an activity of the NAMPT, wherein an increase in the activity of the NAMPT additionally confirms the cell-protective activity of the test compound.
2 more elements
Dependencies are inferred from the claim text.