Application of mRNA for use as a therapeutic against tumour diseases
AssigneeCureVac AG
InventorsIngmar Hoerr, Florian Von Der Mulbe, Steve Pascolo
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Abstract
The present invention relates to a pharmaceutical composition comprising at least one mRNA comprising at least one coding region for at least one antigen from a tumor, in combination with an aqueous solvent and preferably a cytokine, e.g. GM-CSF, and a process for the preparation of the pharmaceutical composition. The pharmaceutical composition according to the invention is used in particular for therapy and/or prophylaxis against cancer.
Claims20
A method of stimulating an antitumour immune response in a subject comprising administering an effective amount of a cell-free composition comprising a mRNA encoding a MUC-1 tumour antigen to a subject having a tumour, thereby stimulating a T-cell mediated cytotoxic antitumor immune response in the subject.
Dependencies are inferred from the claim text.