Histone deacetylase inhibitor of benzamides and use thereof
AssigneesShanghai Institute of Pharmaceutical Industry, Sinopharm A-think Pharmaceutical Co., Ltd, Sinopharm A-Think Medical and Pharmaceutical Research & Development (Beijing) Co., Ltd.
InventorsJianqi Li, Qingwei Zhang, Zhidan Jia, Jiajing Wang
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Abstract
Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumors, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.
Claims3
A compound selected from the group consisting of:
- V-1 N-(4-(2-aminophenylaminocarbonyl)phenyl)-2-naphthamide,
- V-2 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-2-naphthamide,
- V-2′ N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-2-naphthamide hydrochloride,
- V-3 N-(4-(2-aminophenylaminocarbonyl)phenyl)-6-methoxy-2-naphthamide,
- V-4 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-6-methoxy-2-naphthamide,
- V-5 N-(4-(2-aminophenylaminocarbonyl)phenyl)-1H-indole-2-carboxamide,
- V-5′ N-(4-(2-aminophenylaminocarbonyl)phenyl)-1H-indole-2-carboxamide hydrobromide,
- V-6 N-(4-(3-aminopyridine-4-carbamoyl)phenyl)-1H-indole-2-carboxamide,
- V-6′ N-(4-(3-aminopyridine-4-carbamoyl)phenyl)-1H-indole-2-carboxamide sulfate,
- V-7 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-1H-indole-2-carboxamide,
- V-8 N-(4-(2-aminophenylaminocarbonyl)phenyl)benzofuran-2-carboxamide,
- V-8′ N-(4-(2-aminophenylaminocarbonyl)phenyl)benzofuran-2-carboxamide mesylate,
- V-9 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)benzofuran-2-carboxamide,
- V-10 N-(4-(2-amino-5-thienylphenylaminocarbonyl)phenyl)benzofuran-2-carboxamide,
- V-11 N-(4-(2-amino-5-phenylphenylaminocarbonyl)phenyl)benzofuran-2-carboxamide,
- V-12 N-(4-(2-aminophenylaminocarbonyl)phenyl)-1H-benzimidazol-2-carboxamide,
- V-13 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-1H-benzimidazol-2-carboxamide,
- V-13′ N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-1H-benzimidazol-2-carboxamide trifluoroacetate,
- V-14 N-(4-(2-amino-5-furylphenylaminocarbonyl)phenyl)-1H-benzimidazol-2-carboxamide,
- V-15 N-(4-(2-aminophenylaminocarbonyl)phenyl)-1-naphthamide,
- V-16 N-(4-(3-aminopyridine-4-carbamoyl)phenyl)-1-naphthamide,
- V-17 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)-1-naphthamide,
- V-18 N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-fluoro-1H-indole-2-carboxamide,
- V-18′ N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-fluoro-1H-indole-2-carboxamide malate,
- V-19 N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-methyl-1H-indole-2-carboxamide,
- V-20 N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-trifluoromethyl-1H-indole-2-carboxamide,
- V-20′ N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-trifluoromethyl-1H-indole-2-carboxamide maleate,
- V-21 N-(4-(2-aminophenylaminocarbonyl)phenyl)-3-methoxybenzofuran-2-carboxamide,
- V-22 N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-methylamino-1H-indole-2-carboxamide,
- V-23 N-(4-(2-aminophenylaminocarbonyl)phenyl)-5-amino-1H-indole-2-carboxamide,
- V-24 N-(4-(2-aminophenylaminocarbonyl)phenyl)benzothiophene-2-carboxamide,
- V-25 5-acetamido-N-(4-(2-aminophenylaminocarbonyl)phenyl)-1H-indole-2-carboxamide,
- V-26 5-acetyl-N-(4-(2-aminophenylaminocarbonyl)phenyl)-1H-indole-2-carboxamide,
- V-27 N-(4-(2-amino-5-fluorophenylaminocarbonyl)phenyl)benzothiophene-2-carboxamide, and
- V-28 N-(4-(3-aminopyridine-4-carbamoyl)phenyl)benzothiophene-2-carboxamide;
- and salts thereof.
Dependencies are inferred from the claim text.