Benzocycloheptane and benzoxepine derivatives

A method of treating cognitive impairment comprising administering to a warm-blooded mammal in need of such treatment an effective amount of a compound of formula

• including any stereochemically isomeric form thereof, wherein
• A represents phenyl, thienyl, furanyl or a 6-membered aromatic heterocycle containing 1 or 2 nitrogen atoms;
• wherein said phenyl, thienyl, furanyl or 6-membered aromatic heterocycle may optionally be fused with phenyl or a 6-membered aromatic heterocycle containing 1 or 2 nitrogen atoms;
• Z represents CH2 or O;
• R1 represents halo, hydroxyl, C1-4alkyl, C1-4alkyloxy, polyhaloC1-4alkyl, cyano, nitro, amino, mono or di(C1-4alkyl)amino;
• or
• in case A represents phenyl then two adjacent R1 substituents may be taken together to form a radical of formula
• —O—CH2—O— (a-1);
• or
• —O—CH2—CH2—O— (a-2);
• R2 represents hydrogen or C1-4alkyl;
• R3 and R4 each independently represent hydrogen, C1-6alkyl, C1-4alkyloxyC1-6alkyl or phenylC1-4alkyl;
• or
• R3 and R4 are taken together with the nitrogen to which they are attached to form a radical of formula (b-1) or (b-2)
• with X1 representing CH2 or CHOH;
• and X2 representing CH2, O or NR6;
• R5 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy or trifluoromethyl;
• R6 represents hydrogen, C1-4alkyl, C1-4alkylcarbonyl, C1-4alkyloxycarbonyl, phenyloxycarbonyl;
• n represents an integer of value 0, 1, 2, 3, 4 or 5;
• a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof;
• provided that the compound is other than
• or a pharmaceutically acceptable salt thereof.