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US 9,040,697 B2Granted
Process for the production of moxonidine
AssigneeArevipharma GmbH
InventorsHarald Hofmeier, Michael Limmert, Heike Heydemüller, Helge Hartenhauer
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Abstract
4,6-dichloro-2-methyl-5-(1-acyl-2-imidazolin-2-yl)-aminopyrimidine is reacted with methanol in the presence of a non-ionic organic base, and moxonidine is obtained directly from the reaction mixture.
Claims14
A process for the synthesis of moxonidine of formula I
- or a pharmaceutically acceptable salt thereof, the process comprising the steps of:
- reacting a 4,6-dichloro-2-methyl-5-(1-acyl-2-imidazolin-2-yl)-aminopyrimidine derivative of formula II
- wherein R denotes an acyl group;
- with methanol in the presence of a non-ionic organic base;
- and
- obtaining moxonidine (I) from the reaction mixture.
3 more elements
Dependencies are inferred from the claim text.