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US 9,040,668 B2Granted
Anti-serum albumin binding variants
AssigneeGlaxo Group Limited
InventorsElena De Angelis, Carolyn Enever, Haiqun Liu, Oliver Schon, Malgorzata Pupecka-Swider
Life of this patent
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Abstract
The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
Claims9
An anti-serum albumin (SA) immunoglobulin single variable domain comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 412 (DOM7h-11-56), SEQ ID NO:
- 413 (DOM7h-11-57), SEQ ID NO:
- 414 (DOM7h-11-65), SEQ ID NO:
- 415 (DOM7h-11-67), SEQ ID NO:
- 416 (DOM7h-11-68), SEQ ID NO:
- 417 (DOM7h-11-69), SEQ ID NO:418 (DOM7h-11-79), SEQ ID NO:419 (DOM7h-11-80), SEQ ID NO:420 (DOM7h-11-90), SEQ ID NO:421 (DOM7h-11-86), SEQ ID NO:422 (DOM7h-11-87), and SEQ ID NO:423 (DOM7h-11-88).
4 more elements
An anti-SA immunoglobulin single variable domain comprising SEQ ID NO:421 (DOM7h-11-86).
An anti-SA immunoglobulin single variable domain comprising SEQ ID NO:420 (DOM7h-11-90).
Dependencies are inferred from the claim text.