Methods and compositions comprising a C-terminal Bax peptide
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsAnnette Khaled, Rebecca Boohaker, Michael Lee, Jesus Perez Figueroa
Life of this patent
Estimating the term…
Abstract
In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.
Claims18
A method of permeabilizing membranes of cells, comprising, administering to the cell an effective amount of a) a C-terminal B cell lymphoma-2 (Bcl-2)-associated X protein (Bax) peptide (CT20p peptide), wherein the CT20p peptide comprises SEQ ID NO:
- 2, SEQ ID NO:
- 3, or SEQ ID NO:
- 4, or a combination of two or more of SEQ ID NOs:
- 1-4, or b) a composition comprising a CT20p peptide, wherein the composition comprises SEQ ID NO:
- 2, SEQ ID NO:
- 3, or SEQ ID NO:
- 4, or a combination of two or more of SEQ ID NOs:
- 1-4.
A composition for permeabilizing membranes in cells, comprising, a CT20p peptide, wherein the CT20p peptide comprises SEQ ID NO:
- 2, SEQ ID NO:
- 3, or SEQ ID NO:
- 4, or a combination of two or more of SEQ ID NOs:
- 1-4.
Dependencies are inferred from the claim text.