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US 9,040,660 B2Granted
Long-acting gastrin derivatives
AssigneeNovo Nordisk A/S
InventorsJacob Kofoed, Carsten Engaard Stidsen, Frantisek Hubalek, Flemming S. Nielsen, Henning Thoegersen, Johannes Fels, Rikke Bjerring Andersen, Janos Tibor Kodra
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Abstract
The present invention relates to gastrin derivatives comprising gastrin or an analogue or fragment thereof and a derivatisation group and therapeutic use thereof.
Claims3
A gastrin derivative comprising:
- gastrin-17 or an analogue thereof, wherein the analogue is selected from the group consisting of [Leu15] gastrin-17,[Lys3, Leu15] gastrin-17, [Lys8, Leu15] gastrin-17, and [Lys14, Leu15] gastrin-17;
- and
- a derivatisation group comprising a C12-22 acyl group, wherein said derivatisation group is {2-(2-{2-[2-(2-{2-[4-Carboxy-4-(17-carboxyheptadecanoylamino)butyrylamino]ethoxy}-ethoxy)acetylamino]-ethoxy}ethoxy)acetyl}, and wherein said derivatisation group is attached to a position selected from the group consisting of the N-terminal amino group, position 3, 8, and 14 of gastrin-17 or an analogue thereof.
Dependencies are inferred from the claim text.