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US 9,040,658 B2Granted
Thiol-selective water-soluble polymer derivatives
AssigneeNektar Therapeutics
InventorsAntoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
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Abstract
The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
Claims6
A polymer having the following structure:
- POLY-L0,1-X—Y—S—S—Y—X-L0,1-POLY
- wherein:
- POLY is an end-capped polyalkylene oxide;
- L is an optional linker;
- X is selected from the group consisting of amide, carbamate, carbonate ester, ether and thioester;
- Y is selected from the group consisting of alkylene, substituted alkylene, cycloalkylene, substituted cycloalkylene, aryl, and substituted aryl, comprising from about 2 to about 10 carbon atoms;
- and
- S is a sulfur atom.
5 more elements
Dependencies are inferred from the claim text.