Continuous administration of dopa decarboxylase inhibitors and compositions for same
AssigneeNeuroDerm, Ltd.
InventorsOron Yacoby-Zeevi, Mara Nemas
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Abstract
Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
Claims21
A pharmaceutically acceptable liquid composition comprising levodopa, arginine, and about 0.5% to about 3% by weight carbidopa, wherein the pH of the liquid composition is 8 to 10 at 25° C.
A pharmaceutically acceptable liquid composition with a pH of 9.5 at 25° C., comprising about 6% by weight levodopa, about 1 to about 20% by weight arginine, and ascorbic acid.
A pharmaceutically acceptable liquid composition with a pH of 9.5 at 25° C., comprising about 6% by weight levodopa, about 1 to about 20% by weight arginine, about 0.5% to about 3% by weight carbidopa, and ascorbic acid.
Dependencies are inferred from the claim text.