Compositions and methods for treating or preventing pneumovirus infection and associated diseases
AssigneeMicrodose Therapeutx, Inc.
InventorsRobert O. Cook, Eugene R. Reynolds, Boris Shekunov, Siead I. Zegar
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Abstract
The present invention provides novel crystalline polymorphic forms of MDT-637, in particular, crystalline polymorphic forms with physicochemical properties specifically suited for drug production, amorphous formation, composite form, and methods of preparation thereof. The novel polymorphs described herein are useful for the treatment of respiratory disease, such as disease caused by respiratory syncytial virus.
Claims15
A composition comprising at least one polymorph of MDT-637 selected from the group consisting of amorphous form, P-2 hydrate crystal form, P-3 dihydrate crystal form, P-3 ethanolate crystal form, P-3 monohydrate crystal form, P-3 anhydrous crystal form, P-2 anhydrous crystal form, P-4 crystal form, P-6 crystal form, P-7 crystal form, P-8 crystal form, and combinations thereof.
A method of treating a subject having a disease resulting from infection by Paramyxovirinae or Pneumovirinae, comprising administering to the subject a compound in an amount effective to treat the subject wherein the compound comprises at least one polymorph of MDT-637 selected from the group consisting of amorphous form, P-2 hydrate crystal form, P-3 dihydrate crystal form, P-3 ethanolate crystal form P-3 monohydrate crystal form P-3 anhydrous crystal form P-2 anhydrous crystal form P-4 crystal form P-6 crystal form, P-7 crystal form, P-8 crystal form and combinations thereof.
A method of treating a subject having an infection associated with respiratory syncytial virus, comprising administering to the subject a compound in an amount effective to treat the subject wherein the compound comprises eat least one polymorph of MDT-637 selected from the group consisting of amorphous form P-2 hydrate crystal form P-3 dihydrate crystal form, P-3 ethanolate crystal form, P-3 monohydrate crystal form, P-3 anhydrous crystal form, P-2 anhydrous crystal form, P-4 crystal form, P-6 crystal form, P-7 crystal form P-8 crystal form and combinations thereof.
Dependencies are inferred from the claim text.