Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof
AssigneesThe Governors of the University of Alberta, Alberta Health Services
InventorsMichael Weinfeld, Dennis G. Hall, Feridoun Karimi-Busheri, Gary Kenneth Freschauf, Todd Randall Mereniuk
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Abstract
The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.
Claims13
A pharmaceutical composition comprising:
- a first amount of a topoisomerase I inhibitor and a second amount of a polynucleotide kinase/phosphatase (PNKP) inhibitor, and a pharmaceutically acceptable carrier.
A combination comprising a topoisomerase I inhibitor and a polynucleotide kinase/phosphatase (PNKP).
A method of treating a subject suffering from a disorder associated with a defect in DNA polymerase β, comprising administering to said subject an inhibitor of polynucleotide kinase/phosphatase (PNKP).
Dependencies are inferred from the claim text.