Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
AssigneeVertex Pharmaceuticals Incorporated
InventorsDean Shannon, Brian Luisi, Mariusz Krawiec, Anuj K. Kuldipkumar
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Abstract
The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
Claims16
A pharmaceutical composition comprising the hydrochloric acid salt of the compound of formula (I):
- and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
A pharmaceutical composition comprising an amorphous Form III of the 6-fluorobenzimidazolyl urea compound of formula I:
- and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
A pharmaceutical composition comprising an amorphous Form IV of the mesylate salt of the 6-fluorobenzimidazolyl urea compound of formula I:
- and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
Dependencies are inferred from the claim text.