Pyrimidinediamine kinase inhibitors

A method of treating a disease or condition, comprising administering to a mammal a therapeutically effective amount of 6-(2-(2-ethoxy-5-(4-methylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-ylamino)-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one,

• or a solvate, pharmaceutically acceptable salt, or N-oxide thereof, wherein the disease or condition is ductal carcinoma, invasive lobular carcinoma, lobular carcinoma in situ, metastatic breast cancer, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, Kaposi's sarcoma, small cell lung carcinoma, non-small cell lung carcinoma, bronchial adenoma, pleuropulmonary blastoma, malignant mesothelioma, brain stem glioma, hyptothalamic glioma, cerebellar astrocytoma, cerebral astrocytoma, medullablastoma, ependymal tumors, oligodendroglial, meningiomas, neuroectodermal tumor, pineal tumor, prostate cancer, testicular cancer, penile cancer, uterine cancer (endometrial), cervical cancer, ovarian cancer, vaginal cancer, vulval cancer, uterine sarcoma, ovarian germ cell tumor, anal cancer, colon cancer, colorectal cancer, esophageal cancer, gallbladder cancer, stomach (gastric) cancer, pancreatic cancer, pancreatic cancer-Islet cell, rectal cancer, small-intestine cancer, salivary gland cancer, hepatocellular carcinoma, cholangiocarcinoma, mixed hepatocellular cholangiocarcinoma, primary liver cancer, intraocular melanoma, retinoblastoma, rhabdomyosarcoma, laryngeal cancer, hypopharyngeal cancer, nasopharyngeal cancer, oropharyngeal cancers, lip cancer, oral cancer, squamous neck cancer, metastatic paranasal sinus cancer, T cell lymphoma, B cell lymphoma, non-Hodgkin's lymphoma, cutaneous T cell lymphoma, Hodgkin's disease, lymphoma of the central nervous system, acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, hair cell leukemia, thyroid cancer, thymoma, malignant thymoma, bladder cancer, soft tissue sarcoma, osteosarcoma, malignant fibrous histiocytoma, lymphosarcoma, or rhabdomyosarcoma.