Methods and compositions for modulating tau levels
AssigneeThe J. David Gladstone Institutes
InventorLi Gan
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Abstract
Methods and agents for reducing a level of an acetylated Tau polypeptide in a cell are provided. Methods for treating a tauopathy in an individual are also provided. Also provided is a method for diagnosing a cognitive impairment disorder in an individual. Methods for identifying an agent suitable for treating a tauopathy are also provided.
Claims18
A method for reducing the level of an acetylated Tau polypeptide in a cell, the method comprising contacting the cell with an agent that increases the activity of a polypeptide that deacetylates a Tau polypeptide in the cell and/or an agent that decreases the activity of a polypeptide that acetylates a Tau polypeptide in the cell.
A method for treating a tauopathy in an individual, the method comprising administering to the individual an effective amount of an agent that reduces the level of acetylated Tau in a neuron or a glial cell in the individual.
A method of diagnosing a cognitive impairment disorder in an individual, the method comprising detecting a level of acetylated Tau polypeptide in a biological sample obtained from the individual, wherein a level of acetylated Tau polypeptide that is higher than a normal control level indicates that the individual has a cognitive impairment disorder.
Dependencies are inferred from the claim text.