Compounds as diacylglycerol acyltransferase inhibitors
AssigneeGlaxoSmithKline Intellectual Property (No. 2) Limited
InventorsMui Cheung, Raghuram Tangirala
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AssigneeGlaxoSmithKline Intellectual Property (No. 2) Limited
InventorsMui Cheung, Raghuram Tangirala
Estimating the term…
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.
A compound which is 4-amino-6-[1-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5H,6H,7H,8H-pyrimido[5,4-f][1,4]oxazepin-5-one, represented by the formula:
A compound which is 4-amino-6-[1-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-5H,6H,7H,8H-pyrimido[5,4-f][1,4]oxazepin-5-one, represented by the formula:
Dependencies are inferred from the claim text.