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AssigneeAlcon Research, Ltd.
InventorsHoward Allen Ketelson, Ryan Desousa, Nissanke L. Dassanayake, Mary E. Luck
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Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.
A method of using a galactomannan to inhibit uptake of a cationic biocide into hydrogel biomaterials, the method comprising adding to a composition containing a cationic biocide and a borate a galactomannan in an amount to form a concentration between 0.025 to 0.074% w/v, wherein the composition is adapted for use with hydrogel biomaterials.
A method of reversibly binding cationic biocides in solution to inhibit uptake of the biocide into hydrogel biomaterials, the method comprising adding hydroxypropyl guar in an amount to form a concentration between 0.025 to 0.074% w/v to a composition containing a cationic biocide and a borate.
Dependencies are inferred from the claim text.