1,2,3-Triazolyl purine derivatives

A compound having Formula II,

• wherein:
• R1 represents an alkyl, an aryl, —SiR4, —SnR5, —B(R4)2, —B(OH)2, an amide, an imide, or an organometallic;
• R2 and R3 independently represent N, CH, or CR6;
• X represents —OR9, —SR9, or —NR9R10;
• Y represents H, an alkyl, an aryl, or a saccharide moiety;
• R4 independently represents —R5 or —OR5;
• R5, R7 and R8, independently of each other and independently at each position, represent alkyl, cycloalkyl, or aryl;
• and
• R6 independently represents an alkyl or an aryl;
• R9 and R10 independently represent H, an alkyl, or an aryl;
• R7 and R8, R9 and R10 independently, may be combined to represent a heterocyclic alkyl or a heterocyclic aryl;
• alkyl groups are branched or unbranched, saturated or unsaturated, and have 1-18 carbon atoms in their longest chain;
• cycloalkyl groups are carbocyclic or heterocyclic, fused or unfused, non-aromatic ring systems having a total of 5-16 ring members including substituent rings;
• aryl groups are carbocyclic or heterocyclic;
• carbocyclic aryl groups are fused or unfused ring systems having a total of 6-16 ring members including substituent rings;
• heterocyclic aryl groups are fused or unfused ring systems having a total of 5-16 ring members including substituent rings;
• halo substituents are fluoro, chloro, bromo, or iodo;
• each alkyl, cycloalkyl, and aryl, independently, may be unsubstituted or substituted with one or more substituent at any position;
• alkyl substituents are halo, hydroxyl, —OR5, —SR5, —S(O)R4, —S(O)2R4, —NH2, —NHR5, —NR7R8, cycloalkyl, or aryl;
• cycloalkyl substituents are halo, hydroxyl, —OR5, —SR5, —NH2, —NHR5, —NR7R8, alkyl, cycloalkyl, or aryl;
• aryl substituents are halo, hydroxyl, —OR5, —SR5, —NH2, —NHR5, —NR7R8, —CN, alkyl, cycloalkyl, aryl, nitro, or carboxyl;
• and
• heterocyclic alkyl and heterocyclic aryl have at least one heteroatom selected from the group consisting of oxygen, nitrogen and sulfur.

A compound having Formula III,

• wherein:
• R9, R10, R12, R13, R14, R15, R16, and R17 independently represent N or CR11;
• R11 independently represents —R18, —OR19, —SR19, —N(R18)2, R18C(O)—, nitro, or halo;
• R18 independently represents H, an alkyl group, or an aryl;
• R19 independently represents R18 or a protecting group;
• Y represents R18 or a saccharide moiety;
• alkyl groups are branched or unbranched, saturated or unsaturated, and have 1-18 carbon atoms in their longest chain;
• cycloalkyl groups are carbocyclic or heterocyclic, fused or unfused, non-aromatic ring systems having a total of 5-16 ring members including substituent rings;
• aryl groups are carbocyclic or heterocyclic;
• carbocyclic aryl groups are fused or unfused ring systems having a total of 6-16 ring members including substituent rings;
• heterocyclic aryl groups are fused or unfused ring systems having a total of 5-16 ring members including substituent rings;
• halo substituents are fluoro, chloro, bromo, or iodo;
• each alkyl, cycloalkyl, and aryl, independently, may be unsubstituted or substituted with one or more substituent at any position;
• alkyl substituents are halo, hydroxyl, —OR5, —SR5, —S(O)R4, —S(O)2R4, —NH2, —NHR5, —NR7R8, cycloalkyl, or aryl;
• cycloalkyl substituents are halo, hydroxyl, —OR5, —SR5, —NH2, —NHR5, —NR7R8, alkyl, cycloalkyl, or aryl;
• aryl substituents are halo, hydroxyl, —OR5, —SR5, —NH2, —NHR5, —NR7R8, —CN, alkyl, cycloalkyl, aryl, nitro, or carboxyl;
• and
• heterocyclic alkyl and heterocyclic aryl have at least one heteroatom selected from the group consisting of oxygen, nitrogen and sulfur;
• R4 independently represents —R5 or —OR5;
• R5, R7 and R8, independently of each other and independently at each position, represent alkyl, cycloalkyl, or aryl;
• and
• R7 and R8 independently, may be combined to represent a heterocyclic alkyl or a heterocyclic aryl.