Treatment and diagnosis of colon cancer
AssigneeThe Rockefeller University
InventorsSohail F. Tavazoie, Jia M. Loo
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Abstract
The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
Claims26
A method for treating a metastatic gastrointestinal cancer in a subject in need thereof, comprising administering to the subject beta-guanidinopropionic acid in an effective amount to suppress metastatic colonization of said gastrointestinal cancer.
A method of treating metastatic cancer in a subject in need thereof comprising:
- (a) providing a subject identified to have, or to be at risk of having, metastatic cancer on the basis of the expression level of miR-483-5p and/or miR-551a is below a predetermined reference value or the expression level of CKB and/or SLC6a8 is above a predetermined reference value;
- and
- (b) administering to said subject an effective amount of beta-guanidinopropionic acid.
A method for treating metastatic cancer in a subject in need thereof, comprising contacting creatine transport channel SLC6a8 with beta-guanidinopropionic acid in an amount effective to suppress metastatic colonization of said cancer.
Dependencies are inferred from the claim text.