Back to results
US 9,040,494 B2Granted
RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
AssigneeNovartis AG
InventorsAbbot F. Clark, Wan-Heng Wang, Loretta Graves McNatt, Jon E. Chatterton
Life of this patent
Estimating the term…
Abstract
RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
Claims16
A method of attenuating expression of Frizzled Related Protein-1 mRNA of a subject, comprising:
- administering to an eye of the subject a composition comprising an effective amount of interfering RNA and a pharmaceutically acceptable carrier, the interfering RNA comprising:
- a sense nucleotide strand, an antisense nucleotide strand, and a region of at least near-perfect contiguous complementarity between the sense and antisense strands of at least 19 nucleotides;
- wherein the sense strand is 19 to 21 nucleotides, and the antisense strand is 19 to 21 nucleotides and hybridizes to a nucleic acid sequence of SEQ ID NO:
- 98, wherein the thymines are replaced with uracils,
- wherein the expression of Frizzled Related Protein-1 mRNA is attenuated thereby.
2 more elements
A method of treating glaucoma in a subject in need thereof, comprising:
- administering to an eye of the subject a composition comprising an effective amount of interfering RNA, and a pharmaceutically acceptable carrier, the interfering RNA comprising a sense nucleotide strand, an antisense nucleotide strand, and a region of at least near-perfect contiguous complementarity between the sense and antisense strands of at least 19 nucleotides;
- wherein the sense strand is 19 to 21 nucleotides, and the antisense strand is 19 to 21 nucleotides and hybridizes to a nucleic acid sequence of NO:
- 98, wherein the thymines are replaced with uracils,
- wherein the glaucoma is treated thereby.
1 more element
Dependencies are inferred from the claim text.