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US 9,040,487 B2Granted
Cyclosporine emulsion
AssigneeNeurovive Pharmaceutical AB
InventorEskil Elmér
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Abstract
The present invention relates to a cyclosporine emulsion containing: i) a cyclosporine ii) a natural oil (long chain triglyceride) iii) a phosphatidylcholine, iv) glycerol, v) a pharmaceutically tolerable alkali salt of a free fatty acid, vi) a medium chain triglyceride-oil vii) optionally, hydrochloric acid or sodium hydroxide for pH adjustment viii) water.
Claims4
A cyclosporine oil-in-water emulsion comprising
- i) 5 g/L cyclosporine,
- ii) 100 g/L soya bean oil,
- iii) 12 g/L egg lecithin,
- iv) 25 g/L water-free glycerol,
- v) 0.3 g/L sodium oleate,
- vi) 100 g/L medium chain triglyceride-oil selected from the group consisting of coconut oil, palm oil, and combinations thereof, and
- vii) water for injection,
- wherein the emulsion is isoosmolar and has an osmolarity of from 280 to 305 mosm/l, and
- wherein the composition does not contain polyethoxylated castor oil.
6 more elements
Dependencies are inferred from the claim text.