Octapeptide compounds and therapeutic use thereof

An octapeptide compound of general formula (I)

• R-AA1-cyclo(AA2-Tyr3-D-Trp4-AA5-Val6-Cys7)-Thr8-NH2 (I)
• wherein
• (i) AA1 represents an amino acid radical linked to the radical R and to the amino acid AA2 according to the formula
• wherein
• R1 represents a naphthyl radical optionally substituted by one or more alkyl radicals;
• and
• R represents a hydrogen atom, an alkyl or an acetyl radical;
• (ii) AA2 represents an amino acid radical linked to the amino acids AA1 and Tyr3 according to the formula
• wherein n2 represents an integer ranging from 1 to 2;
• and
• (iii) AA5 represents an amino acid radical linked to the amino acids Trp4 and Val6 according to the formula
• wherein R5 and R′5 represent independently a hydrogen atom, an alkyl or an acetyl radical, and n5 represents an integer ranging from 1 to 6;
• and
• if AA2 represents a cysteine amino acid radical, then either:
• AA1 does not represent a naphthylalanine amino acid radical and AA5 represents a lysine amino acid radical;
• AA1 represents a naphthylalanine amino acid radical and AA5 does not represent a lysine amino acid radical;
• or
• AA1 does not represent a radical of naphthylalanine and AA5 does not represent a lysine radical;
• or if AA2 does not represent a cysteine radical, then AA1 represents a naphthylalanine amino acid radical and AA5 represents a lysine amino acid radical,
• and wherein all the amino acids are in D or L configuration;
• or
• a pharmaceutically acceptable salt thereof.