Back to results
US 9,040,481 B2Granted
Methods for treating steatotic disease
AssigneeThe General Hospital Corporation
InventorsJoel F. Habener, Eva Tomas-Falco
Life of this patent
Estimating the term…
Abstract
Methods for treating fatty liver disease, e.g., hepatic steatosis, using peptide fragments of the C-terminal end of glucagon-like peptide-1 (GLP-1), e.g., GLP-1(28-36).
Claims12
A method of treating or preventing a dyslipidemia or a fatty liver disease (FLD) in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a peptide consisting of (Phe/Tyr)-Ile-Ala-Trp-Leu-Val-(Lys/Arg)-Gly-Arg-Xaa (SEQ ID NO:9), wherein Xaa can be Gly, Gly-Arg, Gly-Arg-Gly, or absent, wherein one or more amino acid residues of SEQ ID NO:9 are modified by attachment of a fatty acid.
Dependencies are inferred from the claim text.