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AssigneeProcell Therapeutics Inc.
InventorsDae Woong Jo, Jae Sun Ko, Jin Sook Kim, Kyung Mi Park, Jin Kyung Song, Jung Hee Lim, Thi Thuy Nga Do, Thi Lan Phuong Do, Minh Tam Duong
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The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
An isolated macromolecule transduction domain (MTD) peptide wherein the peptide comprises the amino acid sequence selected from the group consisting of SEQ ID NOs:
An isolated recombinant protein having cell permeability comprising a macromolecule transduction domain (MTD) peptide wherein the MTD comprises the amino acid sequence selected from the group consisting of SEQ ID NOs:
Dependencies are inferred from the claim text.