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US 9,040,299 B2Granted
Generating a mucin-producing cell from an umbilical cord amniotic membrane epithelial stem cell
AssigneeCellresearch Corporation Pte. Ltd.
InventorToan-Thang Phan
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Abstract
The present invention relates to the generation of a mucin-producing cell using stem/progenitor cells obtained from the amniotic membrane of umbilical cord and therapeutic uses of such mucin-producing cells.
Claims7
A method of generating a mucin-producing cell comprising:
- placing umbilical cord amniotic membrane epithelial stem cells (UCEC) in a container;
- culturing the UCEC in the container in a growth medium adapted for the cultivation of a mucin-producing cell through the addition of a growth factor selected from the group consisting of epidermal growth factor (EGF), insulin-like growth factor-1, platelet-derived growth factor-BB (PDGFb), transforming growth factor-β, keratinocyte growth factor (KGF), TGF-αand amphiregulin and combinations thereof;
- and
- permitting the UCEC to differentiate into mucin producing cells as indicated by observing mucin in the culture medium.
1 more element
Dependencies are inferred from the claim text.