Anti-human α9 integrin antibody and use thereof
AssigneeGene Techno Science Co., Ltd.
InventorsShigeyuki Kon, Toshimitsu Uede
Life of this patent
Estimating the term…
Abstract
The present invention relates to an anti-human α9 integrin antibody. More particularly, the present invention relates to: a monoclonal antibody, a chimeric antibody, a humanized antibody and a human antibody that specifically recognize human α9 integrin; a hybridoma cell that produces the monoclonal antibody; a method for producing the monoclonal antibody; a method for producing the hybridoma cell; a therapeutic agent comprising the anti-human α9 integrin antibody; a diagnostic agent comprising the human α9 integrin antibody; and a method for screening for a compound that inhibits the activity of human α9 integrin.
Claims5
A therapeutic agent for a cancer rheumatoid arthritis, osteoarthritis or hepatitis, comprising as an active component an anti-human α9 integrin antibody comprising the amino acid sequences of SEQ ID NOS:1, 3, and 5 as CDRH1, CDRH2, and CDRH3, respectively, of the complementary determining region of the heavy chain (CDRH), and the amino acid sequences of SEQ ID NOS:
- 7, 9 and 11 as CDRL1, CDRL2, and CDRL3, respectively, of the complementary determining region of the light chain (CDRL).
A therapeutic agent for a cancer, rheumatoid arthritis, osteoarthritis or hepatitis, comprising as active components an anti-human α4 integrin antibody and an anti-human α9 integrin antibody comprising the amino acid sequences represented by SEQ ID NOS:1, 3, and 5 as CDRH1, CDRH2, and CDRH3, respectively, of the complementary determining region of the heavy chain (CDRH), and the amino acid sequences of SEQ ID NOS:
- 7, 9 and 11 as CDRL1, CDRL2, and CDRL3, respectively, of the complementary determining region of the light chain (CDRL).
A diagnostic agent for a cancer, rheumatoid arthritis, osteoarthritis or hepatitis, comprising as an active component an anti-human α9 integrin antibody comprising the amino acid sequences of SEQ ID NOS:1, 3, and 5 as CDRH1, CDRH2, and CDRH3, respectively, of the complementary determining region of the heavy chain (CDRH), and the amino acid sequences of SEQ ID NOS:
- 7, 9 and 11 as CDRL1, CDRL2, and CDRL3, respectively, of the complementary determining region of the light chain (CDRL).
A pharmaceutical composition comprising as an active component an anti-human α9 integrin antibody comprising the amino acid sequences of SEQ ID NOS:1, 3, and 5 as CDRH1, CDRH2, and CDRH3, respectively, of the complementary determining region of the heavy chain (CDRH), and the amino acid sequences of SEQ ID NOS:
- 7, 9 and 11 as CDRL1, CDRL2, and CDRL3, respectively, of the complementary determining region of the light chain (CDRL) and a pharmacologically-acceptable carrier, diluent or excipient.
A method for treating an ECM-related disease, said method comprising administering to a subject in need thereof an anti-human α9 integrin antibody comprising the amino acid sequences of SEQ ID NOS:1, 3, and 5 as CDRH1, CDRH2, and CDRH3, respectively, of the complementary determining region of the heavy chain (CDRH), and the amino acid sequences of SEQ ID NOS:
- 7, 9 and 11 as CDRL1, CDRL2, and CDRL3, respectively, of the complementary determining region of the light chain (CDRL), wherein said ECM-related disease is selected from the group consisting of rheumatoid arthritis, osteoarthritis and hepatitis.
Dependencies are inferred from the claim text.