Compounds as L-cystine crystallization inhibitors and uses thereof
AssigneeNew York University
InventorsMichael D. Ward, Jeffrey Rimer
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Abstract
A method of preventing or inhibiting L-cystine crystallization using the compounds of formula I is disclosed. wherein A, L, R1a, R1b, and m are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.
Claims42
A method for inhibiting, or slowing the growth of L-cystine crystallization comprising administering an effective amount of a compound of formula I
- or a pharmaceutically acceptable salt, solvate, cocrystal, or prodrug thereof, and stereoisomers, tautomers and isotopic variants thereof;
- and wherein
- A is
- L is —O—C1-C6 alkylene-O—, —O-aryl-O—, or a group —O—(CH2—CH2—O—)t—;
- the subscript t is 1-10;
- the subscript m is 0-10;
- each R1a and R1b is independently selected from H, alkyl, alkenyl, alkynyl, aryl, aralkyl, and cycloalkyl;
- each R2a, R2b, R3a, R3b, R3c, R3d, R4a, and R4b is independently selected from H, and alkyl;
- and
- each subscript n1 and n2 is independently 0, 1, or 2;
- provided that when each n1 and n2 is 0, then at least one of R1a and R1b is other than H.
A method for inhibiting, or slowing the growth of L-cystine crystallization comprising administering an effective amount of a compound of formula III:
- or a pharmaceutically acceptable salt, solvate, cocrystal, or prodrug thereof, and stereoisomers, tautomers and isotopic variants thereof;
- and wherein
- each R1a and R1b is independently selected from H, alkyl, alkenyl, alkynyl, and cycloalkyl;
- each R2a, R2b, R3a, R3b, R3c, R3d, R4a, and R4b is independently selected from H, and alkyl;
- and
- each n1 and n2 is independently 0, 1, or 2;
- provided that when each n1 and n2 is 0, then at least one of R1a and R1b is other than H.
Dependencies are inferred from the claim text.