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AssigneeBuck Institute for Research on Aging
InventorsMatthew Alan Gregory, Sabine Gaisser, Hrvoje Petkovic, Steven Moss
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The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogs and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogs and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogs, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
A method of generating analogues of FKBP-ligands which incorporate a non-natural starter unit, said method comprising:
Dependencies are inferred from the claim text.