Polynucleotides for use in medicine
AssigneeMax-DelbrüCk-Centrum FüR Molekulare Medizin Berlin-Buch
InventorsMichael Gotthardt, Norbert Hübner, Marion Lewis Greaser, Wei Guo
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Abstract
The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above.
Claims9
A method for diagnosing or monitoring a cardiac disease in a biological sample obtained from a subject, comprising:
- determining the presence of a P638L mutation or a P641L mutation in a RBM20 transcript or in a RBM20 protein in a sample from a human or a rat, respectively, and
- deducing from the presence of at least a P638L mutation according to SEQ ID NO. 5 or at least a P641L mutation according to SEQ ID NO. 6 that the subject suffers from a cardiac disease.
A kit for diagnosing, prognosing, or monitoring a cardiac disease in a subject, comprising
- a means for determining a mutation in a RBM20 transcript or in a RBM20 protein in a biological sample from a human wherein the mutation comprises at least a P638L mutation according to SEQ ID No. 5 or at least a P641L mutation according to SEQ ID NO. 6.
Dependencies are inferred from the claim text.