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US 9,040,081 B2Granted
Use of lipid containing particles comprising Quillaja saponins for the treatment of cancer
AssigneeDuecom
InventorsKefei Hu, Bror Morein
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AssigneeDuecom
InventorsKefei Hu, Bror Morein
Estimating the term…
The present invention relates to the use of lipid containing particles, such as liposomes, iscom and/or iscom matrix and posintros, comprising at least one lipid and at least one saponin for the preparation of a pharmaceutical for the treatment of cancer. The saponins are preferably from Quillaja Saponaria Molina. Further, the particles are also delivery systems for one or several compounds for cancer treatment with complementary mechanisms. More, the invention discloses kit of parts comprising at least two parts, wherein one part comprising at least one saponin fraction which is hydrophobic having a killing effect on cancer cell; and the other part comprising at least one saponin fraction which is comparatively hydrophilic, stimulating and modulating the immune response.
A method for the treatment of cancer wherein an iscom matrix particle comprising at least one lipid selected from cholesterol and phospholipid and at least one saponin, chosen from fraction A and fraction C from Quillaja saponaria Molina or a sub fraction thereof, which particle does not contain cancer antigens, is administered to an individual in need of cancer treatment.
Dependencies are inferred from the claim text.