Orally administrable gallium compositions and methods of use
OwnerLawrence Richard Bernsteininventor
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Abstract
Provided are pharmaceutical gallium compositions that are particularly useful for oral administration. The pharmaceutical compositions include solid, liquid, and paste formulations, which have high oral gallium bioavailability and are suitable for human and veterinary applications. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate, gallium 8-quinolinolonate, or gallium nitrate, together with certain viscosity-increasing agents, such as water-soluble forms of methylcellulose or carboxymethylcellulose.
Claims13
A method for increasing the oral bioavailability of gallium from an orally administered gallium compound, the increase being relative to the oral bioavailability of gallium from the gallium compound when it is orally administered without a pharmaceutically acceptable viscosity-increasing agent, comprising the administration to a human or veterinary subject of a pharmaceutical composition comprising a pharmaceutically acceptable gallium compound and a pharmaceutically acceptable viscosity-increasing agent, wherein said gallium compound is not gallium 8-quinolinolate and the viscosity-increasing agent is water-soluble and not a cross-linked form of carboxymethylcellulose or povidone, and wherein the pharmaceutical composition comprises a viscous liquid or paste.
Dependencies are inferred from the claim text.