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US 9,040,049 B2Granted
ADAM-15 antibodies and immunogenic peptides
AssigneeVasgen Limited
InventorsSalman Rahman, Yatin Patel, Holger Gerhardt, Andrea Emma Lundkvist
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AssigneeVasgen Limited
InventorsSalman Rahman, Yatin Patel, Holger Gerhardt, Andrea Emma Lundkvist
Estimating the term…
The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and siRNA molecules which are capable of inhibiting neovascularization and/or angiogenesis and endothelial cell proliferation. The invention relates to antibodies and antigen-binding fragments thereof with specificity towards the metalloprotease domain of ADAM 15 and to immunogenic peptide(s) that elicits such antibodies. The invention also relates to compositions and kits comprising the antibodies and immunogenic peptide(s) of the invention, as well as methods and uses of the antibodies and antigen-binding fragments thereof and immunogenic peptide(s), as well as siRNA molecules.
An isolated monoclonal antibody or antigen-binding fragment thereof that inhibits neovascularization, wherein the antibody or antigen-binding fragment thereof specifically binds to the catalytic cleft of the ADAM 15 metalloprotease domain and specifically inhibits ADAM 15 metalloprotease activity.
Dependencies are inferred from the claim text.