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US 9,040,033 B2Granted
Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
AssigneeDow Global Technologies LLC
InventorsWarren K. Miller, David K. Lyon, Dwayne T. Friesen, William B. Caldwell, David T. Vodak, Daniel E. Dobry
Life of this patent
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Abstract
Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.
Claims16
A composition comprising:
- an active agent;
- and
- hydroxypropyl methyl cellulose acetate succinate (HPMCAS) having a degree of substitution of methoxy groups (DSM) of ≦1.45, a degree of substitution of acetyl groups (DSAc) of from 1.0 to 1.5, and a combined degree of substitution of acetyl groups (DSAc) and succinoyl groups (DSS) of (DSAc+DSS)≧1.25.
A composition comprising:
- an active agent;
- and
- hydroxypropyl methyl cellulose acetate succinate (HPMCAS) having a degree of substitution of methoxy groups (DSM) of ≦1.45, a degree of substitution of acetyl groups (DSAc) of from 1.0 to 1.5, and a degree of substitution of succinoyl groups (DSS) of ≧0.20.
Dependencies are inferred from the claim text.