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US 9,040,025 B2Granted
Anti-senstivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent
AssigneeRhodia Operations
InventorsRobert Lee Reierson, Todd William Domke
Life of this patent
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Abstract
This invention relates to a composition useful as a dentifrice comprising a surfactant agent consisting essentially of monoalkyl and dialkyl phosphate esters, wherein the ratio of monoesters to diesters is greater than 1, and optionally an abrasive agent consisting essentially of siliceous materials.
Claims34
An oral care composition, comprising:
- water soluble phosphate ester salts;
- at least one anti-caries agent selected from the group consisting of sodium fluoride and sodium monofluorophosphate,
- an abrasive agent, provided that the abrasive agent is not a calcium based abrasive agent, and
- a peroxide tooth whitening agent,
- wherein the composition has an absence of calcium compounds;
- wherein all water soluble phosphate ester salts of the composition consist of one or more water soluble phosphate monoester salts according to structure (I) and one or more water soluble phosphate diester salts according to structure (II), wherein the molar ratio of said one or more monoester salts to said one or more diester salts is from 70:30 to 92:8:
- wherein the phosphate monoester salt according to structure (I) has a phosphate head group of structure (IA)
- and a hydrophobic tail of structure (IB)
- R1O(CnH2nO)a(CmH2mO)b (IB);
- and
- wherein the dialkyl phosphate ester salt according to structure (II) has a phosphate head group of structure (IIA)
- and hydrophobic tails of structures (IIB) and (IIC)
- R2O(CnH2nO)a(CmH2mO)b (IIB),
- (OCmH2m)b(OCnC2n)aOR3 (IIC);
- wherein:
- R1, R2, and R3 are each individually linear or branched, saturated or unsaturated hydrocarbon groups of from 10 to 22 carbon atoms,
- n and m are each individually 2 to 4,
- a and b are each individually 0 to 20,
- one of Z1 and Z2 is alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid, and the other of Z1 and Z2 is hydrogen, alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid, and
- Z3 is alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid;
- wherein the phosphate head groups of the at least one monoalkyl water soluble phosphate ester salt and the at least one dialkyl water soluble phosphate ester salt are for anchoring to calcium hydroxyapatite tooth structure of a tooth, the hydrophobic tails for separating from the respective anchored phosphate head groups by hydrolysis, and the phosphate head groups after hydrolysis for being fixed in place in the calcium hydroxyapatite tooth structure by reaction with calcium in saliva of an oral cavity in which the tooth is located.
18 more elements
An oral care composition consisting of:
- one or more water soluble monoalkyl ester salts and one or more dialkyl phosphate ester salts, wherein the molar ratio of monoester salts to diester salts is from 70:30 to 92:8,
- wherein from about 0.1 percent by weight to about 10 percent by weight of the composition is one or more of water soluble phosphate monoester salts according to structure (I) and one or more water soluble phosphate diester salts according to structure (II):
- wherein the phosphate monoester salt according to structure (I) has a phosphate head group of structure (IA)
- and a hydrophobic tail of structure (IB)
- R1O(CnH2nO)a(CmH2mO)b (IB);
- and
- wherein the dialkyl phosphate ester salt according to structure (II) has a phosphate head group of structure (IIA)
- and hydrophobic tails of structures (IIB) and (IIC)
- R2O(CnH2nO)a(CmH2mO)b (IIB),
- (OCmH2m)b(OCnC2n)aOR3 (IIC);
- wherein:
- R1, R2 and R3 are each individually linear or branched, saturated or unsaturated hydrocarbons of from 10 to 22 carbon atoms;
- n and m of the monoalkyl ester and the dialkyl ester are each individually 2 to 4;
- a and b of the monoalkyl ester and the dialkyl ester are each individually 0 to 20;
- one of Z1 and Z2 is alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine or a protonated basic amino acid;
- and the other of Z1 or Z2 is hydrogen, alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid;
- Z3 is alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid, and
- an abrasive agent, provided the abrasive agent is not a calcium based abrasive agent, wherein the abrasive agent is selected from at least one member of the group consisting of siliceous materials, insoluble sodium metaphosphate, insoluble sodium aluminosilicates, sodium bicarbonate, hydrated silica, colloidal silica, fumed silica;
- a peroxide tooth whitening agent;
- anti-caries agent selected from at least one member of the group consisting of sodium fluoride and sodium monofluorophosphate, wherein sodium trimetaphosphate is an optional additional anti-caries agent;
- at least one additive selected from the group consisting of flavoring agent, sweetening agent, anti-calculus agent, buffering agent, and flow aids, alcohol, sudsing agent, preservatives, vitamins, anti-plaque agents, anti-staining compounds, anionic polymers, organic binder, inorganic thickener, nonionic surfactants, coloring agents, pigments, and tetrasodium pyrophosphate;
- wherein the sweetening agent is at least one of saccharin and sorbitol;
- wherein the anti-calculus agents are at least one of water soluble alkali metal salt of a polyphosphate;
- wherein the buffering agent is selected from the group consisting of alkali metal orthophosphate, phosphoric acid, alkali metal glycerophosphates, tartrates and citrates;
- wherein the anti-plaque agents are selected form the group consisting of stannous salts, copper salts, and magnesium salts;
- wherein the anti-staining agents are silicone polymers;
- wherein the anionic polymers are selected from at least one member selected from the group consisting of polycarboxylates, polysulfonates, carboxylate and sulfonate copolymers, phosphonate polymers, and polyphosphates;
- wherein the organic binder is selected from the group consisting of cellulose gum, glycerin, hydroxycellulose, hydroxypropyl cellulose, xanthan gum, Irish moss, and gum tragacanth;
- wherein the inorganic thickener is silica;
- wherein the composition has an absence of calcium compounds;
- optionally a liquid selected from the group consisting of water, humectant, binder, and mixtures thereof, wherein said humectant is at least one member selected from the group consisting of glycerin, sorbitol, polyethylene glycols, polypropylene glycol, and hydrogenated partially hydrolyzed polysaccharides;
- wherein the phosphate head groups of the at least one monoalkyl water soluble phosphate ester salt and the at least one dialkyl water soluble phosphate ester salt anchor to calcium hydroxyapatite tooth structure of the tooth, the hydrophobic tails separate from the respective anchored phosphate head groups by hydrolysis, and the phosphate head groups after hydrolysis are fixed in place in the calcium hydroxyapatite tooth structure by reaction with calcium in saliva of an oral cavity in which the tooth is located;
- wherein the composition has an absence of strontium salts;
- wherein surfactant of the composition consists of the water soluble phosphate ester salts and optional nonionic surfactant.
31 more elements
Dependencies are inferred from the claim text.