US 9,040,022 B2 · Compositions and methods using microspheres and non-ionic contrast agents

Abstract

The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.

Claims22

Dependent claims

A substantially spherical microsphere comprising:

a biocompatible polymeric material comprising polyvinylalcohol,
doxorubicin in a concentration of about 10 mg to about 400 mg of doxorubicin per 100 mg of dry microspheres, and
a non-ionic contrast agent containing iodine, wherein the concentration of the non-ionic contrast agent is from about 100 mg to about 3200 mg iodine per 100 mg of dry microspheres,
wherein the microsphere is swellable in a pharmaceutically acceptable solution and has a diameter of from about 10 μm to about 1000 μm before swelling, and wherein the diameter of the microsphere is from about 40 μm to about 2000 μm after swelling.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

14/180,983Filed 14 Feb 2014 · continuation

Priority

9 May 2005

Published

US 2014/0314678 A123 Oct 2014

Granted

26 May 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 49/1818
Characterised by a special physical form, e.g. emulsions, microcapsules, liposomes: particles, e.g. uncoated or non-functionalised microparticles…
A61K 9/5026
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 31/704
Attached to a carbocyclic compound, e.g. phloridzin: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin,…
A61K 33/243
Heavy metals; Compounds thereof: platinum; Compounds thereof

Family

Application60/679,348Us provisional application · filed 9 May 2005

Application11/430,789Parent of this continuation · filed 9 May 2006

Application13/435,520Parent of this continuation · filed 30 Mar 2012

US 8,226,926 B2Parent of this continuation · filed 24 Jul 2012

US 2014/0314678 A1Pre-grant publication · published 23 Oct 2014

US 8,709,384 B2Parent of this continuation

US 2006/0251582 A1Published application

US 2012/0189552 A1Published application

US 9,040,022 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions and methods using microspheres and non-ionic contrast agents

Life of this patent

Compositions and methods using microspheres and non-ionic contrast agents

Life of this patent

Abstract

Claims22