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US 9,040,021 B2Granted
Heterocyclic compounds as imaging probes of tau pathology
AssigneeGe Healthcare Limited
InventorsClare Jones, Amanda Ewan, Duncan Wynn, Alessandra Gaeta, James Nairne
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Abstract
Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
Claims4
A compound of Formula (IV):
- wherein R1 is independently H, halogen, OH, COOH, SO3H, NH2, NO2, CONHNH2, alkyl, or alkoxy;
- R2 is independently H, halogen, OH, COOH, SO3H, NH2, NO2, CONHNH2, alkyl, or alkoxy;
- n is an integer from 0-4;
- and
- m is an integer from 0-2;
- wherein at least one of R1 and R2 is optionally a radionuclide or optionally substituted with a radionuclide;
- and
- wherein F is optionally 18F.
5 more elements
Dependencies are inferred from the claim text.