Muteins of hNGAL and related proteins with affinity for a given target
AssigneeTechnische Universitaet Muenchen
InventorsArne Skerra, Andreas Eichinger, Hyun-Jin Kim
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Abstract
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
Claims20
A mutein derived human neutrophil gelatinase-associated lipocalin (hNGAL) comprising at least 3 mutated amino acid residues at any of the sequence positions corresponding to the sequence positions 33, 36, 41, 52, 54, 68, 70, 79, 81, 134, 136 and 138 of the linear polypeptide sequence of hNGAL (SEQ ID NO:
- 1), wherein the mutein binds a given target with detectable affinity.
Dependencies are inferred from the claim text.