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US 9,039,896 B2Granted
Device for removing protein-based substances
AssigneeHepa Wash GmbH
InventorBernhard Kreymann
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Abstract
The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.
Claims19
A method for dialysis of a biological fluid containing at least one protein-binding substance to be removed, comprising the following steps:
- (a) passing the biological fluid through a first chamber of a first dialyser wherein the first chamber forms part of a biological fluid circuit,
- (b) passing a dialysis fluid containing a substance that functions as an adsorber for the substance to be removed from the biological fluid through a second chamber of the first dialyser wherein the second chamber forms part of a dialysis fluid circuit,
- (c) at least partially solubilizing the protein binding substance to be removed in the dialysis fluid by adjusting the pH of the dialysis fluid to 1-7 upstream of a second dialyser,
- (d) passing the dialysis fluid with the pH adjusted to 1-7 through the second dialyser forming part of the dialysis fluid circuit, and
- (e) adjusting the pH of the dialysis fluid to 8-13 downstream of the second dialyser.
2 more elements
Dependencies are inferred from the claim text.