Mediator for test sensor
AssigneeBayer HealthCare LLC
InventorsKaren L. Marfurt, Henry C. Arndt
Life of this patent
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Abstract
A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.
Claims40
A test sensor including a base, the base including an enzyme adapted to react with an analyte, and a mediator, the mediator having a background current being less than 200 nA after being exposed to a temperature of 50° C. for a duration of two weeks and further including a neutralizing agent, the neutralizing agent being present in an amount to obtain a pH in a range below 7 to about 5.5 in a mediator solution.
A test sensor including a reagent, the reagent including a mediator and a neutralizing agent, the reagent having a % bias being within 2.4% between 0 and 400 mg/dL of glucose after being exposed to a temperature of 50° C. for a duration of two weeks, the neutralizing agent being present in an amount to obtain a pH in a range below 7 to about 5.5 in a mediator solution.
A test sensor including electrodes and a reagent including glucose dehydrogenase (GDH), a mediator and a neutralizing agent, the reagent having a % bias being within 2.4% between 0 and 400 mg/dL of glucose after being exposed to a temperature of 50° C. for a duration of two weeks, the neutralizing agent being present in an amount to obtain a pH in a range below 7 to about 5.5 in a mediator solution.
A test sensor including a base, the base including an enzyme adapted to react with an analyte, and a 3-phenylimino-3H-phenothiazine mediator, the 3-phenylimino-3H-phenothiazine mediator having a background current being less than 200 nA after being exposed to a temperature of 50° C. for a duration of two weeks and further including a neutralizing agent, the neutralizing agent being present in an amount to obtain a pH in a range below 7 to about 6 in a mediator solution.
A test sensor including a base, the base including an enzyme adapted to react with an analyte, and a 3-phenylimino-3H-phenothiazine mediator, the 3-phenylimino-3H-phenothiazine mediator having a background current being less than 200 nA after being exposed to a temperature of 50° C. for a duration of two weeks and further including a neutralizing agent, the neutralizing agent being present in an amount to obtain a pH of about 6.1 in a mediator solution.
Dependencies are inferred from the claim text.