Systems and methods for delivering radiation therapy

A gynecological brachytherapy applicator comprising:

• a porous and compliant matrix in the form of a substantially cylindrical conformable elongate body having a proximal end and a distal end,
• a central catheter at least partially received in the porous and compliant matrix, and at least one pair of opposed peripheral catheters at least partially received in the porous and compliant matrix;
• wherein the maximum distance between the at least one pair of opposed peripheral catheters being in a range from 70% to equal to or smaller than 100% of the outer diameter of the elongate body, wherein the elongate body has an initial expanded configuration, an unexpanded configuration for advancement of the applicator to a target tissue, and an expanded deployed configuration, wherein the conformable elongate body is imageable by computed tomography,
• wherein the elongate body provides a collapsible and expandable matrix of support such that a position and spacing of the central catheter relative to the at least one pair of opposed peripheral catheters within the porous and compliant matrix are stabilized in the expanded deployed configuration and the initial expanded configuration, and wherein the elongate body is made of a material comprising a foam.