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US 9,022,915 B2Granted
Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
AssigneeGammaTile LLC
InventorsPeter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
Life of this patent
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Abstract
Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
Claims22
A carrier system comprising:
- one or more permanently implantable radioactive seed carriers configured to hold radioactive seeds in precise locations relative to a treatment area of mammalian tissue, wherein the one or more radioactive seed carriers are configured to fit in a cavity in the mammalian tissue near the treatment area;
- wherein the one or more radioactive seed carriers each comprise a biocompatible material having a first surface and an opposing second surface defining a uniform thickness therebetween, and the radioactive seeds are embedded in respective radioactive seed carriers at an offset position between first and second surfaces of the respective radioactive seed carrier such that the radioactive seeds are closer to the first surface than to the second surface of the respective radioactive seed carrier.
A carrier system comprising:
- at least two individual permanently implantable radioactive seed carriers comprising:
- at least one tile carrier comprising
- a biocompatible material having a first surface and an opposing second surface defining a uniform thickness therebetween,
- a radioactive seed embedded at an offset position between the first surface and the opposing second surface of the biocompatible material such that the radioactive seed is closer to the first surface than to the second surface of the at least one tile carrier, and
- a layer of tantalum, tungsten, titanium, gold, silver, or alloys of these or other high Z materials as a foil, grid or strip, the layer configured to diminish penetration of radiation into adjacent normal tissues;
- and
- at least one gore carrier comprising
- a biocompatible material forming a three-dimensional structure with a hollow center, and
- a radioactive seed embedded in the biocompatible material;
- wherein each radioactive seed carrier is configured to hold radioactive seeds in precise locations relative to a treatment area to produce a dosimetrically customizable implant in real-time for the treatment area;
- and
- wherein the carrier system is configured for intraoperative permanent brachytherapy in treatment of tumors.
9 more elements
An implantable apparatus comprising:
- a permanently implantable substrate having a uniform thickness between a first surface and an opposing second surface;
- and
- a radioactive seed positioned at an offset position between the first surface and the opposing second surface of the substrate such that the radioactive seed is closer to the first surface than to the second surface of the substrate.
Dependencies are inferred from the claim text.