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US 9,006,510 B2Granted
Genetically modified heart valve xenografts
AssigneeMayo Foundation for Medical Education and Research
InventorsGuerard W. Byrne, Christopher G. A. McGregor
Life of this patent
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Abstract
A method for producing a heart valve xenograft from bovine tissue expressing reduced or undetectable levels of I1-3 galactosyl transferase are provided.
Claims2
A method for providing a patient with a xenograft, said method comprising implanting into the heart of said patient a fixed bovine heart valve xenograft, wherein cells of said xenograft, prior to being fixed, contain a homozygous disruption in the endogenous α1-3 galactosyl transferase nucleic acid sequence and do not express α1-3 galactosyl transferase.
Dependencies are inferred from the claim text.