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US 9,006,448 B2Granted
Process for the preparation of benzimidazole derivatives and its salts
AssigneeMsn Laboratories Private Limited
InventorsManne Satyanarayana Reddy, Chakilam Nagaraju, Srinivasan Thirumalai Rajan, Sajja Eswaraiah, Achampeta Kodanda Ramprasad, Suraparaju Raghuram
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Abstract
An dabigatran etexilate intermediate of Formula-6a, and the use in the preparation of dabigatran etexilate thereof.
Claims16
A process for preparing dabigatran etexilate compound of Formula-1
- or a salt thereof, the process comprising:
- a) reacting a compound of Formula-2
- with a compound of Formula-3
- in a solvent selected from an ester solvent, an ether solvent, a hydrocarbon solvent, a polar aprotic solvent, a ketone solvent, an alcoholic solvent, a chloro solvent, a nitrile solvent or a nitro solvent, or a mixture thereof, to provide a compound of Formula-4,
- b) reacting the compound of Formula-4 with a compound of Formula-5
- or a compound of Formula-6
- in the presence of a base selected from an inorganic base or an organic base, or a mixture thereof, in a solvent selected from an ester solvent, an ether solvent, a hydrocarbon solvent, a polar aprotic solvent, a ketone solvent, an alcoholic solvent, a chloro solvent, a nitrile solvent or a nitro solvent, or a mixture thereof, to provide the compound of Formula-1.
4 more elements
Dependencies are inferred from the claim text.